The Neurobiology of NO and OH
ANNALS OF NEW YORK ACADEMY OF SCIENCES (VOLUME 738)

Published by The New York Academy of Sciences
New York, New York
November 17, 1994


Chiueh, Chuang C.; Gilbert, Daniel L.; Colton, Carol A., Preface (Page xi)


Part I. Instroduction


Gilbert, Daniel L., Keeping Reactive Oxygen Species (ROS) In their Proper Place. (Page 1)

Part II. Generation and Detection of Reactive Oxygen Species Including NO


Cohen, Gerald, Enzymatic/Nonenzymatic Sources of Oxyradicals and Regulation of Antioxidant Defenses. (Page 8)

Hall, Edward D.; Andrus, Paula K.; Yonkers, Patricia A.; Smith, Sarah L.; Zhang, Jue-Rong; Taylor, Bruce M.; and Sun, Frank F. Generation and Detection of Hydroxyl Radical Following Experimental Head Injury. (Page 15)

Chiueh, C. C.; Wu, R.-M.; Mohanakumar, K. P.; Sternberger, L. M.; Krishna, G.; Obata, T.; and Murphy, D. L. In Vivo Generation of Hydroxyl Radicals and MPTP-Induced Dopaminergic Toxicity in the Basal Ganglia. (Page 25)

Joseph, J. A.; and Cutler, R. C. The Role of Oxidative Stress in Signal Transduction Changes and Cell Loss in Senescence. (Page 37)

Carney, John M.; Smith, Charles D.; Carney, Ann M.; and Butterfield, D. Alan. Aging-and Oxygen-induced Modifications in Brain Biochemistry and Behavior. (Page 44)

Colton, Carol A.; Snell, Julie; Chernyshew, Olga; and Gilbert, Daniel L. Induction of Superoxide Anion and Nitric Oxide Production in Cultured Microglia. (Page 54)

Youdim, Moussa B. H.; Lavie, Lena; and Riederer, Peter. Oxygen Free Radicals and Neurodegeneration in Parkinson's disease: A Role for Nitric Oxide. (Page 64)

Beckman, Josoph S. Peroxynitrite versus Hydroxyl Radical: The Role of Nitric Oxide in Superoxide-Dependent Cerebral Injury. (Page 69)

Dawson, Ted M.; Dawson, Valina L.; and Snyder, Solomon H. Molecular Mechanisms of Nitric Oxide Actions in the Brain. (Page 76)


Part III. Antioxidant Enzymes, Defense Mechanisms, and Transgenic Models


Rhee, S. G.; Kim, K. H.; Chae, H. Z.; Yim, M. B.; Uchida, K.; Netto, L. E. S.; and Stadtman, E. R. Antioxidant Defense Mechanisms: A New Thiol-Specific Antioxidant Enzyme. (Page 86)

Chan, P. H.; Epstein, C. J.; Kinouchi, H.; Kamii, H.; Imaizumi, S.; Yang, G.; Chen, S. F.; Gafni, J.; and Carlson, E. SOD-1 Transgenic Mice as a Model for Studies of Neuroprotection in Stroke and Brain Trauma. (Page 93)

Mirault, Marc-Edouard; Tramblay, Alain; Furling, Denis; Trépanier, Genèvieve; Durgré,Francine; Puymirat, Jack; and Pothier, François. Transgenic Glutathione Peroxidase Mouse Models for Neuroprotection Studies. (Page 104)

Poirier, Judes; Dea, Doris; Baccichet, Annie; and Thiffault, Christine. Superoxide Dismutase Expression in Parkinson's Disease. (Page 116)


Part IV. Reactive Oxygen Species Including NO in Neural Function


Pellmar, T. C.; Gilman, S. C.; Keyser, D. O.; Lee, K. H.; Lepinski, D. L.; Livengood, D.; and Myers, L. S., Jr. Reactive Oxygen Species on Neural Transmission. (Page 121)

Oliveira, C. R.; Agostinho, P.; Caseiro, P.; Duarte, C. B.; and Carvalho, A. P. Reactive Oxygen Species on GABA Release. (Page 130)

Ramassamy, Charles; Girbe, Franck; Pincemail, Joël; Christen, Yves; and Costentin, Jean. Modifications of the Synaptosomal Dopamine Uptake and Release by Two Systems Generating Free Radicals: Ascorbic Acid/Fe2+ and L-Arginine/NADPH. (Page 141)

Volterra, Andrea; Trotti, David; Floridi, Stefano; and Racagni, Giorgio. Reactive Oxygen Species Inhibit High-Affinity Glutamate Uptake: Molecular Mechanism and Neuropathological Implications. (Page 153)

Kandasamy, S. B. Role of Nitric Oxide Synthase, Superoxide Dismutase, and Glutathione Peroxidase in Radiation-Induced Decrease in Norepinephrine Release. (Page 163)

Hanbauer, Ingeborg; Cox, George W.; and Wink, David A. Synaptic and Extrasynaptic Action of Free Radicals on Cell-to-Cell Signaling. (Page 173)

Ruda, M. A.; Besse, D.; Inagaki, S.; DeLeón, M.; and Ren, K. Nitric Oxide Expression and Regulation in the Dorsal Root Ganglion and Spinal Cord. (Page 181)

Nisticò, G.; Bagetta, G; Iannone, M.; and del Duca, C. Evidence that Nitric Oxide Is Involved in the Control of Electrocortical Arousal. (Page 191)

Gutteridge, John M. C. Hydroxyl Radicals, Iron, Oxidative Stress, and Neurodegeneration. (Page 201)


Part V. Novel Antioxidants and Their Neuroprotective Mechanisms


Wu, Ruey-Meei; Mohanakumar, Kochupurackal P.; Murphy, Dennis L.; and Chiueh, Chuang C. Antioxidant Mechanism and Protection of Nigral Neurons Against MPP+ Toxicity by Deprenyl (Selegiline). (Page 214)

Kondo, Tomoyoshi; Ito, Takashi; and Sugita, Yukihiro. Bromocriptine Scavenges Methamphetamine-Induced Hydroxyl Radicals and Attenuates Dopamine Depletion in Mouse Striatum. (Page 222)

Yue, Tian L.; Lysko, Paul G.; Barone, Frank C.; Gu, Juan L.; Ruffolo, Robert R., Jr.; and Feuerstein, Giora Z. Carvedilol, A New Antihypertensive Drug with Unique Antioxidant Activity: Potential Role in Cerebroprotection. (Page 230)

Thomas, Craig E.; Carney, John M.; Bernotas, Ronald C.; Hay, David A.; and Carr, Albert A. In Vitro and In Vivo Activity of a Novel Series of Radical Trapping Agents in Model Systems on CNS Oxidative Damage. (Page 243)

Clemens, James A.; and Panetta, Jill A. Neuroprotection by Antioxidants in Models of Global and Focal Ischemia. (Page 250)

Packer, Lester, Antioxidant Properties of Lipoic Acid and Its Therapeutic Effects in Prevention of Diabetes Complications and Cataracts. (Page 257)

Wink, David A.; Hanbauer, Ingeborg; Laval, François; Cook, John A.; Krishna, Murali C.; and Mitchell, James B. Nitric Oxide Protects Against the Cytotoxic Effects of Reactive Oxygen Species. (Page 265)

Chiueh, C. C. Neurobiology of NO and OH: Basic Research and Clinical Relevance. (Page 279)


Part VI. Recent Advances in ROS Research


Balcioglu, A. and Maher, T. J. The Measurement of Nitric Oxide Release Induced by Kainic Acid Using a Novel Hemoglobin-trapping Technique with Microdialysis. (Page 282)

van Muiswinkel, F. L.; Steinbusch, H. W. M.; Drukarch, B.; and de Vente, J. Identification of NO- producing and -receptive Cells in Mesencephalic Transplants in a Rat Model of Parkinson's Disease: A Study Using NADPH-d Enzyme- and NOSc/cGMP Immunocytochemistry. (Page 289)

Pögün, Sakire and Kuhar, Michael J. Regulation of Neurotransmitter Reuptake by Nitric Oxide. (Page 305)

Papa, M.; Pellicano, M. P.; and Sadile, A. G. Nitric Oxide and Long-Term Habituation to Novelty in the Rat. (Page 316)

Feinstein, Douglas L.; Galea, Elena; and Reis, Donald J. Suppression of Glial iNOS Expression by Tyrosine Kinase Inhibitors. (Page 325)

Ter Horst, Gert J.; Knollema Siert; Stuiver, Bauke; Hom, Harold; Yoshimura, Shinichi; Ruiters, Marcel H. J.; and Korf, Jacob. Differential Glutathione Peroxidase mRNA Up-Regulations in Rat Forebrain Areas after Transient Hypoxia-Ischemia. (Page 329)

Delbarre, Bernard; Delbarre, Gisèle; and Calinon, François. Action of Trimetazidine on Retina of Gerbils after Ischemia Reperfusion Insult: Determination of OH, Amino Acids, and Electroretinogram. (Page 334)

Verrecchia, C.; Buisson, A.; Lakhmeche, N.; Plotkine, M.; and Boulu, R. G. Nitric Oxide and Cerebral Ischemia. (Page 341)

Kovách, A. G. B.; Lohinai, Z.; Marczis, J.; Balla, I.; Dawson, T. M. and Snyder, S. H. The Effect of Hemorrhagic Hypotension and Retransfusion and 7-Nitro-Indazole on rCBF, NOS Catalytic Activity, and Cortical NO Content in the Cat. (Page 348)

Sato, Shinya; Tominaga, Teiji; Ohnishi, Tomoko and Ohnishi, S. Tsuyoshi. Role of Nitric Oxide in Brain Ischemia. (Page 369)

Blasig, I. E.; Mertsch, K.; Ladhoff, A.; and Grune, T. Lipid Peroxidation and Lipofuscin Granula in Brain Endothelial Cell Cultures during Reoxygenation. (Page 374)

Alayash, Abdu I. and Cashon, Robert E., Reactions of Nitric Oxide and Hydrogen Peroxide with Hemoglobin-Based Blood Substitutes. (Page 378)

Lipton, Stuart A.; Singel, David J.; and Stamler, Jonathan S., Neuroprotective and Neurodestructive Effects of Nitric Oxide and Redox Congeners. (Page 382)

Cadet, Jean Lud; Ali, Syed; and Epstein, Charles, Involvement of Oxygen-based Radicals in Methamphetamine- induced Neurotoxicity: Evidence from the Use of CuZnSOD Transgenic Mice. (Page 388)

Mohanakumar, K. P.; de Bartolomeis, A.; Wu, R.-M.; Yeh, K. J.; Sternberger, L. M.; Peng, S.-Y.; Murphy, D. L.; and Chiueh, C. C., Ferrous-Citrate Complex and Nigral Degeneration: Evidence for Free-radical Formation and Lipid Peroxidation. (Page 392)

Wood, Katherine A. and Youle, Richard J., Apoptosis and Free Radicals. (Page 400)

Vanquelin, Georges; del Rio, Marlene Jimnez; and Pardo, Carlos Velez, Serotonin Binding Proteins: An In Vivo Model System for Monoamine-related Neurotoxicity. (Page 408)

Poeggeler, Burkhard; Saarela, Seppo; Reiter, Russel J.; Tan, Dun-Xian; Chen, Li-Dun; Manchester, Lucien C.; and Barlow-Walden, Lornell R., Melatonin-A Highly Potent Endogenous Radical Scavenger and Electron Donor: New Aspects of the Oxidation Chemistry of this Indole Accessed in vitro. (Page 419)

Loeffler, D. A.; Demaggio, A. J.; Juneau, P. L.; Havaich, M.; and Lewitt, P. A., Levodopa Administration to Normal Rats: Influence on Striatal Oxidized Glutathione Concentration. (Page 421)

Kutty, R. Krishnan; Kutty, Geetha; Nagineni, Chandrasekharam N.; Hooks, John J.; Chader, Gerald J.; Wiggert, Barbara, RT-PCR Assay for Heme Oxygenase-1 and Heme Oxygenase-2: A Sensitive Method to Estimate Cellular Oxidative Damage. (Page 427)

Cheng, Y.; Chen, M.; Wixom, P.; and Sun, A. Y., Extracellular ATP May Induce Neuronal Degeneration by a Free radical Mechanism. (Page 431)

Mitrovic, Branislava; St. Pierre, Barbara A.; Mackenzie-Graham, Allan J.; and Merrill, Jean E., The Role of Nitric Oxide in Glial Pathology. (Page 436)

Smith, Mark, A.; Richey, Peggy L.; Taneda, Shinji; Kutty, R. Krishnan; Sayre, Laurence M.; Monnier, Vincent M.; and Perry, George. Advanced Maillard Reaction End Products, Free Radicals, and Protein Oxidation in Alzheimer's Disease. (Page 447)

Garrel, Catherine; Lafond, Jean-Luc; Guiraud, Pascale; Faure, Patrice; and Favier, Alain. Induction of Production of Nitric Oxide in Microglial Cells by Insoluble Form of Aluminum. (Page 455)

Minc-Golomb, Dahlia and Schwartz, Joan P. Expression of Both Constitutive and Inducible Nitric Oxide Synthases in Neuronal and Astrocyte Cultures. (Page 462)


Index of Contributors. (Page 469)